case western reserve university

Division of Pediatric Pulmonology


Tracey Bonfield, Ph.D. D(ABMLI)

Assistant Professor
BRB Room 822
(216) 368 4558 Office
(216) 368 4376 Lab


Certified by the American Board of Medical Laboratory Immunologists 2006,
Ph.D. Case Western Reserve University, 1991. Institute of Pathology,
M.S. CWRU, 1987 Institute of Pathology,
B.S. John Carroll University 1983, Departments of Biology and Chemistry. 

Fellowships and Training:  Pediatric Pulmonology, Case Western Reserve University:  Cystic Fibrosis Cytokines and Lung Pathology.  Pulmonary Critical Care and Allergy, Cleveland Clinic Foundation: Exploring mechanisms of inflammation associated adult chronic inflammatory lung diseases: sarcoidosis, pulmonary alveolar proteinosis, interstitial lung fibrosis and asthma.

Additional training: T-cell function and activation due to integrin ligand cross-linking, CWRU, Department of Dermatology.


Research Interest

Mechanisms of controlling lung inflammation in the context of injury and infection.



Bonfield, T.L., Thomassen, M.J., Farver, C.F., Susamma, A., Koloze, M.F., Zhang, X., Mosser, D.M. Culver, D.A.
"Peroxisome Proliferator Activator Receptor Gamma Regulates Macrophage Production of Macrophage Colony Stimulating Factor."
2008. J. Immunol. 181:235-241.

Bonfield, T.L., Barna, B.P., John, N., Malur, A. Culver, D.A., Kavuru M.S., THomassen, M.J.
"Suppression of activin A in autoimmune lung disease associated with anti-GM-CSF."
2006. J Autoimmun. 26:37-41.

Bonfield, T.L., Swaisgood, C.M., Barna, B.P., Farver, C.M., Kavuru, M.S., Thomassen, M.J.
"Elevated Gelatinase Activity in Pulmonary Alveolar Proteinase: Role of Macrophage Colony Stimulating Factor."
2006.  J. Leukocyte. Biol. 79:133-139.

Bonfield, T.L., John, N, Barna, B, Kavuru, M, Thomassen, MJ, Yen-Lieberman, B.
" Multiplex Particle-based Anti-Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) Assay: A Pulmonary Diagnostic Test."
2005 Clin. Diagn Lab Immunol 12:821-824

Bonfield, T.L., John, N., Malur, A., Barna, B.P., Culver, D.A., Kavuru, M.S., Thomassen, M.J.
" Elevated Monocyte Chemotactic Proteins 1, 2, and 3 in Pulmonary Alveolar Proteinosis (PAP) Are Associated with Chemokine Receptor Suppression."
2005. Clin. Immunol. 114:79-85

Bonfield T.L., Raychaudhuri B., Malur A.,  Abraham S., Trapnell B.C., Kavuru M.S., Thomassen M.J.
"PU.1 regulation of Human Alveolar Macrophage Differentiation Requires Granulocyte-Macrophage Colony Stimulating Factor."
2003. Am. J. Physiol. Lung Cell Mol. Physiol.  285:L1132-6.

Bonfield T.L., Farver C., Malur A., Abraham S., Raychaudhuri B., Kavuru M.S., Barna B., Thomassen M.J.
"PPARg Expression is Deficient in Pulmonary Alveolar Proteinosis Alveolar Macrophages."
2003. Am. J. Respir. Cell Mol. Biol. 29:677-682.

Bonfield T.L., Thomassen M.J., Kavuru M.S.
"Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) Autoantibody Titer Predicts Response to GM-CSF Therapy in Pulmonary Alveolar Proteinosis."
2002. Clin. Immunol. 105:342-350.