Craig A. Hodges, Ph.D.
(216) 368-0008 Phone
(216) 368-4223 Fax
Dr. Hodges received his B.S. in Biology from Berry College in 1996 and his Ph.D. in Genetics from Case Western Reserve University in 2002. His graduate training was in the laboratory of Dr. Patricia Hunt where his studies focused on the genetics of chromosome segregation during meiosis and infertility using mouse models. Dr. Hodges then undertook postdoctoral training with Dr. Steven Stice at the University of Georgia studying early embryo dysfunction of clones from nuclear transfer using pigs and cows as model systems. Dr. Hodges returned to Case Western Reserve University to train with Dr. Terry Hassold using mouse models to study chromosome segregation and reproduction. In 2005, Dr. Hodges joined the laboratories of Dr. Mitchell Drumm and Dr. Mark Palmert in which he created two conditional Cftr mouse models that are currently being used to study various aspects of the disease Cystic Fibrosis. Dr. Hodges joined the faculty of the Department of Pediatrics at Case Western Reserve University in 2009.
CF is a systemic disease affecting many parts of the body including pulmonary, gastrointestinal, pancreatic, immune, endocrine and reproductive systems. With this in mind, we are interested in determining the extent to which specific cell types contribute to CF disease characteristics, whether the pathophysiology can be halted or reversed by CFTR functional correction and understanding the molecular mechanisms behind the physiological consequences of CFTR’s absence. We are beginning to address these issues through the use of newly created CF mouse models that allow for the conditional inactivation or restoration of Cftr function in specific tissues, cell types as well as at specific developmental timepoints. My laboratory is particularly interested in how the loss of Cftr leads to the observed neuroendocrine abnormalities observed in CF.
Hodges, C.A., Cotton, C.U., Palmert, M.R., Drumm, M.L. "Generation of a conditional null allele for Cftr in mice." Genesis. 46(10):546-55, 2008
Hodges, C.A., Palmert, M.R., Drumm, M.L. "Cystic Fibrosis Related Female Infertility is Multifactorial: Evidence from Mouse Models of CF." Endocrinology 149(6):2790-2797, 2008.
Hodges C.A. and Palmert MR. " Genetic regulation of the variation in pubertal timing. In: E.C. Walvoord and O.H. Pescovitz, editors. When Puberty is Precocious: Scientific and Clinical Aspects. The Humana Press, Totowa, NJ; 83-102, 2007
Nathan, B.M., Hodges, C.A., Palmert, M.R. "The Use of Mouse Chromosome Substitution Strains to Investigate the Genetic Regulation of Pubertal Timing." Molecular and Cellular Endocrinology; 254-255: 103-108, 2006
Nathan, B.M., Hodges, C.A., Supelak, P.J., Burrage, L.C., Nadeau, J.H., Palmert, M.R. "Identification of a Quantitative Trait Locus that Regulates the Onset of Puberty." Endocrinology. 147(11): 5132-5138, 2006
Jin R., Hodges, C.A., Drumm, M.L., Palmert, M.R. "The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulates the Timing of Puberty in Mice." Journal of Medical Genetics 43(6): e29, 2006
Hodges, C.A., Revenkova, E., Jessberger, R., Hassold, T., Hunt, P.A. "The SMC1b-deficient female mouse: Evidence that cohesins are a missing link in age-related nondisjunction." Nature Genetics 37(12): 1351-1355, 2005
Mann, M.B., Hodges, C.A., Barnes, E., Vogel, H., Hassold, T.J., Luo, G. "Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thompson syndrome." Human Molecular Genetics, 14(6): 813-25, 2005.
Revenkova, E., Eijpe, M., Heyting, C., Hodges, C.A., Hunt, P.A., Liebe, B., Scherthan, H., Jessberger, R. "SMC1b is required for meiotic chromosome dynamics, sister chromatid cohesion, and DNA recombination" Nature Cell Biology, 6(6): 555-562, 2004
Bosch, P., Hodges, C.A., Stice, S.L. Generation of transgenic livestock by somatic cell nuclear transfer. Biotechnologia Aplicada, 21(3): 128-136, 2004.
Hodges, C.A., Stice, S.L. "Generation of bovine transgenics using somatic cell nuclear transfer." Reproductive Biology and Endocrinology, 1(1):81-87, 2003.
Hunt, P.A., Koehler, K., Susiarjo, M., Hodges, C.A., Ilagan, A., Voigt, B., Thomas, B., Thomas, S., Hassold, T.J. "Bisphenol A exposure causes meiotic aneuploidy in the female mouse." Current Biology, 13(7):546-553, 2003
Hodges, C.A., Hunt, P.A. "Simultaneous analysis of chromosomes and chromosome-associated proteins in mammalian oocytes and embryos." Chromosoma, 111(3):165-169, 2002.
Hodges, C.A., Ilagan, A., Jennings, D., Keri, R., Nilson, Hunt, P.A. Experimental evidence that changes in oocyte growth influence meiotic chromosome segregation." Human Reproduction, 17(5):1171-80, 2002.
Hodges, C.A., LeMaire-Adkins, R., Hunt, P.A. "Coordinating the segregation of sister chromatids during the first meiotic division: Evidence for sexual dimorphism." Journal of Cell Science, 114(13):2417-26, 2001.
Woods, L.M., Hodges, C.A., Baart, E., Baker, S.M., Liskay, M., Hunt, P.A. "Chromosomal influence on meiotic spindle assembly: Abnormal meiosis I in female MLH1 mutant mice." Journal of Cell Biology, 145(7):1395-406, 1999